Science.News
27.11.2024

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Science.News
Nov 27, 2024

New CRISPR system stops genes instead of permanently switching them off

Scientists have unveiled a new version of the famous gene editing tool CRISPR, which can temporarily “pause” a specific gene instead of permanently turning it off. The original CRISPR system recognizes a specific DNA sequence and then cuts out that part of the DNA strand, permanently turning off the gene. Unfortunately, this technique involves risks, such as “off-target” cuts where the wrong genes are cut. Researchers at Vilnius University in Lithuania have now developed a new, more versatile genetic tool, the Type IV-A CRISPR system. A study published on October 29 in the journal Nature Communications describes how the system switches off genes in an unpredictable way and gives researchers more control over gene activity.

Source

Čepaitė, R., Klein, N., Mikšys, A. et al. Structural variation of types IV-A1- and IV-A3-mediated CRISPR interference. Nat Commune 15, 9306 (2024). https://doi.org/10.1038/s41467-024-53778-1