Science
ABOUT science
The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.
SCIENCE.
NEWS
9.10.2025
Ubiquitin-Vorläufer fördert Stressresistenz und Langlebigkeit
News
October 9, 2025
News
October 9, 2025
Ubiquitin-Vorläufer fördert Stressresistenz und Langlebigkeit
Forscherinnen und Forscher der Universität zu Köln und der Heinrich-Heine-Universität Düsseldorf haben eine neue Form des Proteins Ubiquitin identifiziert, die für die Proteostase, also das Proteingleichgewicht, und gesundes Altern verantwortlich ist. Die Studie zeigt, dass Ubiquitin, das am Ende verlängert ist (CxUb) zur Stressresistenz von Zellen beiträgt. Diese Entdeckung eröffnet potenziell neue Perspektiven für die Behandlung von Krebs und altersbedingten Krankheiten.
Quelle
Altin, Selver et al., Molecular Cell, Volume 85, Issue 19, 3677 - 3693.e7
5.10.2025
Vitamin D May Slow Aging, According to a Study
News
October 6, 2025
News
October 6, 2025
Vitamin D May Slow Aging, According to a Study
A new study suggests that vitamin D may protect the sensitive chromosome caps associated with aging, potentially reducing the risk of age-related diseases.
Quelle
“Vitamin D3 and marine ω-3 fatty acids supplementation and leucocyte telomere length: 4-year findings from the Vitamine D and Omega-3 trial (VITAL) randomized controlled trial” by Haidong Zhu, JoAnn E Manson, Nancy R Cook, Bayu B Bekele, Li Chen, Kevin J Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee and Yanbin Dong, 21 May 2025, The American Journal of Clinical Nutrition. DOI: 10.1016/j.ajcnut.2025.05.003
21.9.2025
Scientists discover hidden drivers of aging that can potentially be reversed
News
September 22, 2025
News
September 22, 2025
Scientists discover hidden drivers of aging that can potentially be reversed
A drop in the protein menin in the brain's hypothalamus appears to be a major factor in aging by triggering inflammation and loss of important neurotransmitters. Mouse studies show that restoring menin or supplementing with the amino acid D-serine improves cognitive abilities, bone density, skin thickness, and balance — suggesting a potential way to slow or even reverse aspects of aging.
Quelle
Leng L, Yuan Z, Su X, Chen Z, Yang S, Chen M, et al. (2023) Hypothalamic menin regulates systemic aging and cognitive decline. PLoS Biol 21 (3): e3002033. https://doi.org/10.1371/journal.pbio.3002033
21.9.2025
New biomarker could identify Alzheimer's years before symptoms occur
News
September 22, 2025
News
September 22, 2025
New biomarker could identify Alzheimer's years before symptoms occur
A new study suggests that TSPO, a key biomarker of inflammation in the brain, can identify the earliest stages of Alzheimer's disease long before symptoms occur.
Quelle
Martinez-Perez, D. A., McGlothan, J. L., Rodichkin, A. N. et al. Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer's disease. Acta Neuropathol 150, 6 (2025). https://doi.org/10.1007/s00401-025-02912-4
17.9.2025
Leading scientists are rethinking the medical approach to aging
News
September 17, 2025
News
September 17, 2025
Leading scientists are rethinking the medical approach to aging
An important new study in the Journal of the American Medical Association (JAMA) highlights a new medical approach that could revolutionize the fight against aging processes and diseases. Instead of treating heart disease, cancer, or kidney disease individually, researchers argue for tackling the biological processes of aging themselves — an approach known as geroscience.
Quelle
“Geroscience: A Translational Review” by Stephen B. Kritchevsky and Steven R. Cummings, August 7, 2025, JAMA. DOI: 10.1001/jama.2025.11289
SCIENCE.
EXPLAINED
Aging
Alterung
Telomeres shorten over the course of a lifetime. The normal aging process is thought to be affected by telomere shortening and thus associated with the onset of disease and increased mortality in old age.
Length
Länge
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells are no longer able to perform their functions. This is thought to be one of the mechanisms of aging.
Function
Funktion
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells become less able to perform their functions. This is thought to be one of the mechanisms of aging.
Schutz
Through prevention and proactive measures. Eating habits: high consumption of meat (especially red meat), a generally fatty diet and obesity cause the chromosome caps to wear down, as does excessive alcohol consumption. Consumption of vegetable products protects the cells.
Physical activity: Interval and endurance training can lengthen telomeres
Protetion
Science.
Quote
The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.
George Church
American geneticist, molecular engineer, chemist, and "founder of genomics"
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