Science
ABOUT science
The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.
SCIENCE.
NEWS
10.2.2025
Alzheimer's biomarker test can detect disease years before onset
News
February 10, 2025
News
February 10, 2025
Alzheimer's biomarker test can detect disease years before onset
Researchers have developed a biomarker test for Alzheimer's disease that can detect tau protein, which tends to clump, and its misfolded pathological forms in brain scans, possibly years before the neurofibrillary tangles occur.
Quelle
Islam, T., Hill, E., Abrahamson, E. E. et al. Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease. Nat Med (2025). https://doi.org/10.1038/s41591-024-03400-0
10.2.2025
Daily omega-3 supplementation and regular exercise may slow the aging process
News
February 10, 2025
News
February 10, 2025
Daily omega-3 supplementation and regular exercise may slow the aging process
A new study suggests that omega-3 and vitamin D supplements combined with regular physical exercise may help slow down the biological aging process by several months over a period of three years.
Quelle
Bischoff-Ferrari, H.A., Gägler, S., Wieczorek, M. et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nat Aging (2025). https://doi.org/10.1038/s43587-024-00793-y
12.1.2025
Scientists uncover mitochondrial key
News
January 12, 2025
News
January 12, 2025
Scientists uncover mitochondrial key
New research shows that E-TCmito is an important link between neuronal activity and mitochondrial function, highlighting its potential to counteract cognitive decline in old age and in diseases such as Alzheimer's.
Quelle
Wenwen Li, Jiarui Li, Jing Li, Chen Wei, Tal Laviv, Meiyi Dong, Jingran Lin, Mariah Calubag, Lesley A Colgan, Kai Jin, Bing Zhou, Ying Shen, Haohong Li, Yihui Cui, Zhihua Gao, Hailan Hu, Ryohei Yasuda and Huan Ma, 20 December 2024, Science.
9.1.2025
When muscles are exercised, they help nerve cells grow
News
January 9, 2025
News
January 9, 2025
When muscles are exercised, they help nerve cells grow
The results of a new study suggest that the biochemical and physical effects of exercise could contribute to nerve healing.
Quelle
A. Bu, F. Afghah, N. Castro, M. Bawa, S. Kohli, K. Shah, B. Rios, V. Butty, R. Raman, Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons. Adv. Healthcare Mater. 2024, 2403712. https://doi.org/10.1002/adhm.202403712
8.1.2025
Ketone bodies eliminate damaged proteins in the brain
News
January 8, 2025
News
January 8, 2025
Ketone bodies eliminate damaged proteins in the brain
Ketone bodies, which are known for their role in energy metabolism during fasting, have been shown to interact directly with damaged proteins in the brain and promote their breakdown through autophagy. The researchers found that the ketone body β-hydroxybutyrate alters the solubility of the misfolded proteins, which facilitates their breakdown and reduces pathological aggregation.
Quelle
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00459-8
SCIENCE.
EXPLAINED
Aging
Alterung
Telomeres shorten over the course of a lifetime. The normal aging process is thought to be affected by telomere shortening and thus associated with the onset of disease and increased mortality in old age.
Length
Länge
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells are no longer able to perform their functions. This is thought to be one of the mechanisms of aging.
Function
Funktion
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells become less able to perform their functions. This is thought to be one of the mechanisms of aging.
Schutz
Through prevention and proactive measures. Eating habits: high consumption of meat (especially red meat), a generally fatty diet and obesity cause the chromosome caps to wear down, as does excessive alcohol consumption. Consumption of vegetable products protects the cells.
Physical activity: Interval and endurance training can lengthen telomeres
Protetion
Science.
Quote
The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.
George Church
American geneticist, molecular engineer, chemist, and "founder of genomics"
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