Science
ABOUT science
The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.
SCIENCE.
NEWS
26.3.2025
Cellular age clocks show interindividual heterogeneity during infection and vaccination
News
March 31, 2025
News
March 31, 2025
Cellular age clocks show interindividual heterogeneity during infection and vaccination
Researchers create AI-supported computer model that makes aging visible on a cellular level for the first time
Quelle
Li, W., Zhang, Z., Kumar, S. et al. Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination. Nat Aging (2025). https://doi.org/10.1038/s43587-025-00819-z
26.3.2025
Verbal Fluency Selectively Predicts Survival in Old and Very Old Age
News
March 26, 2025
News
March 26, 2025
Verbal Fluency Selectively Predicts Survival in Old and Very Old Age
A new study shows that among the various cognitive abilities, language fluency in particular is associated with a longer life in old age.
Quelle
Ghisletta, P., Aichele, S., Gerstorf, D., Carollo, A., & Lindenberger, U. (2025). Verbal Fluency Selectively Predicts Survival in Old and Very Old Age. Psychological Science, 36 (2), 87-101. https://doi.org/10.1177/09567976241311923 (original work published 2025)
26.3.2025
Biological age prediction using a DNN model based on steroidogenesis pathways
News
March 26, 2025
News
March 26, 2025
Biological age prediction using a DNN model based on steroidogenesis pathways
Scientists from Osaka University have developed an AI model that estimates biological age based on hormone analyses and links stress to accelerated aging.
Quelle
Qiuyi Wang et al. , Biological age prediction using a DNN model based on pathways of steroidogenesis.sci. Adv.11, eadt2624 (2025) .doi:10.1126/sciadv.adt2624
18.3.2025
New protein discovery could be key to healthier aging
News
March 18, 2025
News
March 18, 2025
New protein discovery could be key to healthier aging
Scientists at McMaster University have made a breakthrough discovery about the protein MANF, which plays a crucial role in cell health and aging. MANF supports cell purification by preventing the formation of toxic proteins that can lead to neurodegenerative diseases such as Alzheimer's and Parkinson's.
Quelle
S.K.B. Taylor, J.H. Hartman, & B.P. Gupta, The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans, Proc. Natl. Acad. Sci. United States 121 (43) e2403906121, https://doi.org/10.1073/pnas.2403906121 (2024)
14.3.2025
New therapies to stimulate bone growth
News
March 18, 2025
News
March 18, 2025
New therapies to stimulate bone growth
Researchers at ETH Zurich have presented high-resolution spatial data on gene activity in bone cells for the first time. They thus show that mechanical stimuli influence the activity of genes in bones. Such stimuli could therefore be used specifically for therapeutic applications. The results could pave the way for new therapeutic approaches against bone loss and for faster bone healing after bone fractures.
Quelle
Neashan Mathavan et al. , Spatial transcriptomics in bone mechanomics: Exploring the mechanoregulation of fracture healing in the era of spatial omics.sci. Adv.11, eadp8496 (2025) .doi:10.1126/sciadv.adp8496
SCIENCE.
EXPLAINED
Aging
Alterung
Telomeres shorten over the course of a lifetime. The normal aging process is thought to be affected by telomere shortening and thus associated with the onset of disease and increased mortality in old age.
Length
Länge
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells are no longer able to perform their functions. This is thought to be one of the mechanisms of aging.
Function
Funktion
Telomeres are protective caps at the ends of chromosomes that shorten each time a cell divides. When they become so short that the genes they protect could be damaged, cells stop dividing and renewing themselves. As a result, the cells become less able to perform their functions. This is thought to be one of the mechanisms of aging.
Schutz
Through prevention and proactive measures. Eating habits: high consumption of meat (especially red meat), a generally fatty diet and obesity cause the chromosome caps to wear down, as does excessive alcohol consumption. Consumption of vegetable products protects the cells.
Physical activity: Interval and endurance training can lengthen telomeres
Protetion
Science.
Quote
The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.
George Church
American geneticist, molecular engineer, chemist, and "founder of genomics"
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