Science
ABOUT science
The biology of aging is still largely a mystery. Researchers are working hard to unravel the molecular and cellular causes of aging and to find ways to prevent age-related diseases. These discoveries, and the science that may help people stay healthy as they age, are reported here.
SCIENCE.
NEWS
12.1.2025
Scientists uncover mitochondrial key
News
January 12, 2025
News
January 12, 2025
Scientists uncover mitochondrial key
New research shows that E-TCmito is an important link between neuronal activity and mitochondrial function, highlighting its potential to counteract cognitive decline in old age and in diseases such as Alzheimer's.
Quelle
Wenwen Li, Jiarui Li, Jing Li, Chen Wei, Tal Laviv, Meiyi Dong, Jingran Lin, Mariah Calubag, Lesley A Colgan, Kai Jin, Bing Zhou, Ying Shen, Haohong Li, Yihui Cui, Zhihua Gao, Hailan Hu, Ryohei Yasuda and Huan Ma, 20 December 2024, Science.
9.1.2025
When muscles are exercised, they help nerve cells grow
News
January 9, 2025
News
January 9, 2025
When muscles are exercised, they help nerve cells grow
The results of a new study suggest that the biochemical and physical effects of exercise could contribute to nerve healing.
Quelle
A. Bu, F. Afghah, N. Castro, M. Bawa, S. Kohli, K. Shah, B. Rios, V. Butty, R. Raman, Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons. Adv. Healthcare Mater. 2024, 2403712. https://doi.org/10.1002/adhm.202403712
8.1.2025
Ketone bodies eliminate damaged proteins in the brain
News
January 8, 2025
News
January 8, 2025
Ketone bodies eliminate damaged proteins in the brain
Ketone bodies, which are known for their role in energy metabolism during fasting, have been shown to interact directly with damaged proteins in the brain and promote their breakdown through autophagy. The researchers found that the ketone body β-hydroxybutyrate alters the solubility of the misfolded proteins, which facilitates their breakdown and reduces pathological aggregation.
Quelle
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00459-8
8.1.2025
Resveratrol and vitamin C reduce oxidative stress after menopause
News
January 8, 2025
News
January 8, 2025
Resveratrol and vitamin C reduce oxidative stress after menopause
In a randomized controlled trial published in the journal Nutrients, researchers tested supplementation with resveratrol, vitamin C, and a combination of the two. They found that all treatments had a similar positive effect on oxidative stress in postmenopausal women.
Quelle
Montoya-Estrada A, Garcia-Cortés AY, Romo-Yañez J, Ortiz-Luna GF, Arellano-Eguiluz A, Belmont-Gomez A, Lopez-Ugalde V, León-Reyes G, Flores-Pliego A, Espejel-Nuñez A, Solis-Paredes JM, Reyes-Muñoz E. The Administration of Resveratoz E. Role and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clinical Trial. Nutrients. 2024 Nov 3; 16 (21) :3775. doi: 10.3390/nu16213775. PMID: 39519608; PMCID: PMC11548005.
4.12.2024
Skin transplantation of senescent cells results in age-related peripheral dysfunction and cognitive decline
News
December 4, 2024
News
December 4, 2024
Skin transplantation of senescent cells results in age-related peripheral dysfunction and cognitive decline
Mayo Clinic researchers have discovered that senescent cells — non-dividing zombie cells — build up in the skin as we age and can influence the aging process in other parts of the body. Their latest study showed that transplanting aging skin cells in a preclinical model not only led to the spread of aging to other tissues, but also accelerated physical decline, impaired muscle function, and worsened brain health. This discovery suggests that senescent cells in the skin could cause wider systemic aging.
Quelle
Franco, A.C., Martini, H., Victorelli, S., Lagnado, A.B., Wyles, S.P., Rowsey, J.L., Pirius, N., Woo, S., Costa, D.G., Chaib, S., Tullius, S.G., Kirkland, J.L., Khosla, S., Jurk, D., Cavadas, C. & Passos, J. F. (2024). Senescent cell transplantation into the skin induces age-related peripheral dysfunction and cognitive decline. Aging Cell. https://doi.org/10.1111/acel.14340
SCIENCE.
EXPLAINED
Science.
Quote
The goal of a genome analysis is not to find out what you will die of, but rather to learn how to prevent diseases from occurring.
George Church
American geneticist, molecular engineer, chemist, and "founder of genomics"