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May 5, 2026
Loneliness Is a Health Issue
What science now knows about social connection and how we age
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NMN (nicotinamide mononucleotide) is the immediate precursor of NAD+, an essential coenzyme and important metabolic partner that is found in every cell in the human body and is involved in over 500 different cell reactions. NAD+ is synthesized by the cell through various pathways, some of which are more complex than others. The primary route of NAD+ synthesis involves the conversion of nicotinamide (NAM) to NMN and the subsequent conversion of NMN to NAD+. As an immediate precursor to NAD+, NMN is a highly efficient precursor that requires the fewest steps and the least amount of energy to convert to NAD+.

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