Science.News
12.7.2024

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Science.News
Jul 12, 2024

Suppressed basal mitophagy results in cellular aging phenotypes that can be reversed by a small molecule that targets p62

Highlights of the study: - Basal mitophagy is very active in various primary human cells in culture. - PINK1, Parkin and p62 are essential for basal mitophagy in primary fibroblasts - The loss of mitophagy results in cellular senescence phenotypes and is evident during aging. - Mitophagy activators protect against senescence/aging-related changes in cell function

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DOI: https://doi.org/10.1016/j.devcel.2024.04.020