Science.News
Jul 1, 2024
Lifespan in Mice Shortens with Increase in Nutrient Signaling to mTOR
As the aging population increases, the race to unpack the molecular understanding of aging heats up. The rapamycin (mTOR) complex 1 (mTORC1) is known to be a key component of multiple functions of the body, including metabolism. Now, a new paper finds that when mTOR activity is just slightly increased in mice, the lifetime of animals can be shortened by up to 20%.
Source
Ortega-Molina, A., Lebrero-Fernández, C., Sanz, A. et al. A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00635-x
