This review examines the crucial role of telomere biology in the aging process, in which telomere degradation acts both as a protective mechanism and as a contributor to tissue degeneration and age-related diseases. Given increasing life expectancy and the associated burden on health systems, strategies to promote healthy aging and curb age-related diseases are crucial. The study outlines recent research efforts aimed at influencing telomere shortening, including research on telomerase activators, tankyrase inhibitors, and the effects of antioxidants, anti-inflammatories, and statins, and highlights their potential to promote wellbeing, healthy aging, and longevity.