Science.News
8.1.2025

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Science.News
Jan 8, 2025

Ketone bodies eliminate damaged proteins in the brain

Ketone bodies, which are known for their role in energy metabolism during fasting, have been shown to interact directly with damaged proteins in the brain and promote their breakdown through autophagy. The researchers found that the ketone body β-hydroxybutyrate alters the solubility of the misfolded proteins, which facilitates their breakdown and reduces pathological aggregation.

Source

https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00459-8