Science.News
Sep 13, 2024
Strength training activates cellular waste disposal
An international research team led by the University of Bonn has discovered that the BAG3 protein, which is responsible for disposing of damaged cell components, is activated through strength training. This activation is crucial for maintaining muscle cells and can help prevent heart failure and muscle weakness. The results are also important for the treatment of nerve diseases in which a malfunction of the BAG3 system leads to the death of nerve fibers. The findings could enable new therapeutic approaches and improvements in training and rehabilitation.
Source
Judith Ottensmeyer, Alessandra Esch, Henrique Baeta, Sandro Sieger, Yamini Gupta, Maximilian F. Rathmann, Andreas Jeschke, Daniel Jacko, Kirill Schaaf, Thorsten Schiffer, Bahareh Rahimi, Lukas Lövenich, Angela Sisto, Peter F.M. van der Ven, Dieter O. Fürst, Albert Haas, Wilhelm Bloch, Sebastian Gehlert, Bernd Hoffmann, Vincent Timmerman, Pitter F. Hüsgen, Jörg Höhfeld, Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic, Current Biology, 2024, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2024.07.088
