The Power of 13: A Glimpse into the World of Longevity Molecules
The science behind the MoleQlar ONE complex and its effect on the aging process
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At a time when striving for longer and healthier lives has become a central concern for many people, science has made significant progress in researching the biological mechanisms of aging. As a result of these efforts, a wide variety of molecules have been identified that have the potential to slow down the aging process and improve health over time.
A notable innovation in this area is MoleQlar ONE, a complex developed in close collaboration with experts for daily use. This product features a unique formula that includes 13 different Longevity ingredients combined, whose effectiveness has been proven by scientific research.
A look at these carefully selected ingredients reveals a fascinating network of molecules, each of which plays a specific role in promoting longevity.
The main ingredient of MoleQlar ONE is calcium alpha ketoglutarate (AKG), a molecule that not only supports muscle and bone growth, but, according to initial findings, can also slow down biological aging. This effect could be partly due to supporting energy metabolism and promoting a healthy microbiome.
Trans-resveratrol, another ingredient, has attracted researchers' attention as it increases the activity of sirtuins, also known as longevity genes. It also shows promising antioxidant properties that make cells more resistant to oxidative stress do.
Luteolin, a flavonoid that is able to eliminate defective cells and reduce inflammatory responses in the body, is another important component of this formula. By activating NAD, an important enzyme in energy metabolism, it also helps maintain cell function.
Quercetin, also a flavonoid, has shown promise in activating the longevity signaling pathway AMPK* and contributes to senescent cells, which can play a role in various diseases in old age, to reduce more efficiently.
*AMPK is an enzyme that controls energy metabolism and is involved in regulating processes such as glucose metabolism, mitochondrial function, and inflammatory responses.
Glycine, an amino acid, shows impressive results in animal studies in extending life and influencing various aspects of aging, such as reducing blood sugar levels in diabetics over the long term and improving blood pressure in patients with high blood pressure.
The list continues with theanine, hyaluronic acid, glucosamine, inositol, creatine, magnesium taurate, L-citrulline malate and vitamin C, each of which makes a unique contribution to promoting health and longevity.
The MoleQlar ONE formula combines the best of current research to create a holistic anti-aging experience to offer. With a unique combination of 13 ingredients, it aims to produce various Characteristics of aging to influence — from strengthening the immune system to supporting energy metabolism and reducing inflammation to improving cognitive functions and muscle strength. Thanks to a science-based approach and dosing based on proven research, this product offers a promising opportunity to promote health in old age and enable a longer, more fulfilling life.
It is recommended to take one sachet (1 serving) of MoleQlar ONE daily, with the contents dissolved in 250 ml of liquid and drunk.
References
- Zdzisiñska, B., Żurek, A. & Kandefer‐Szerszeń, M. (2016). Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use. Archivum Immunologiae Et Therapiae Experimentalis, 65(1), 21–36. https://doi.org/10.1007/s00005-016-0406-x
- Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer, F. R., Kennedy, B. K. & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8-year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging, 13(22), 24485–24499. https://doi.org/10.18632/aging.203736
- Li, F., Weikel, K., Cacicedo, J. M. & Ido, Y. (2017). Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients, 9(7), 751. https://doi.org/10.3390/nu9070751
- Keylor, M. H., Matsuura, B. S. & Stephenson, C. R. J. (2015). Chemistry and Biology of Resveratrol-Derived Natural Products. Chemical Reviews, 115(17), 8976–9027. https://doi.org/10.1021/cr500689b
- Akter, R., Afrose, A., Rahman, M. R., Chowdhury, R., Nirzhor, S. S. R., Khan, R. I. & Kabir, M. T. (2021). A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes. International Journal Of Molecular Sciences, 22(8), 4180. https://doi.org/10.3390/ijms22084180
- Liu, Y. J., Janssens, G. E., McIntyre, R. L., Molenaars, M., Kamble, R., Gao, A. W., Jongejan, A., Van Weeghel, M., MacInnes, A. W. & Houtkooper, R. H. (2019). Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLOS Genetics, 15(3), e1007633. https://doi.org/10.1371/journal.pgen.1007633
- Kumar, P., Li, C., Suliburk, J. W., Hsu, J. W., Muthupillai, R., Jahoor, F., Minard, C. G., Taffet, G. E. & Sekhar, R. V. (2022). Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. The Journals Of Gerontology: Series A, 78(1), 75–89. https://doi.org/10.1093/gerona/glac135
Publiziert
22.7.2024
Kategorie
Lifestyle
Experte
Scientific Terms
Sirtuin
Enzymes that control longevity: They are found in organisms ranging from yeast to humans and require NAD to function. They remove acetyl and acyl groups from proteins to instruct them to protect cells from adversity, disease, and death. When fasting or exercising, sirtuin and NAD levels rise, which could explain why these activities are healthy. The SIRT genes (Sir2 homologues 1 to 7), which are named after the SIR2 gene in yeast, play a key role in protecting mammals against disease and decay.
NAD
Nicotinamide adenine nucleotide, a chemical used for more than five hundred chemical reactions and for sirtuins, which remove aceryl groups from other proteins, such as histones, to turn off genes or give them cell protective functions. A healthy diet and exercise increase NAD levels. The “+” sign that you sometimes see, as in NAD, indicates that it has no hydrogen aroma.
Cellular Senescence
The process that occurs when normal cells stop dividing and start releasing inflammatory molecules, sometimes caused by telomere shortening, DNA damage, or epigenomic noise. Despite their apparent “zombie” state, senescent cells remain alive and damage neighboring cells with their inflammatory secretions.
Amino Acid
The chemical component of proteins. During the reaction, various amino acids are strung together to form a chain that folds to form a protein.
At a time when striving for longer and healthier lives has become a central concern for many people, science has made significant progress in researching the biological mechanisms of aging. As a result of these efforts, a wide variety of molecules have been identified that have the potential to slow down the aging process and improve health over time.
A notable innovation in this area is MoleQlar ONE, a complex developed in close collaboration with experts for daily use. This product features a unique formula that includes 13 different Longevity ingredients combined, whose effectiveness has been proven by scientific research.
A look at these carefully selected ingredients reveals a fascinating network of molecules, each of which plays a specific role in promoting longevity.
The main ingredient of MoleQlar ONE is calcium alpha ketoglutarate (AKG), a molecule that not only supports muscle and bone growth, but, according to initial findings, can also slow down biological aging. This effect could be partly due to supporting energy metabolism and promoting a healthy microbiome.
Trans-resveratrol, another ingredient, has attracted researchers' attention as it increases the activity of sirtuins, also known as longevity genes. It also shows promising antioxidant properties that make cells more resistant to oxidative stress do.
Luteolin, a flavonoid that is able to eliminate defective cells and reduce inflammatory responses in the body, is another important component of this formula. By activating NAD, an important enzyme in energy metabolism, it also helps maintain cell function.
Quercetin, also a flavonoid, has shown promise in activating the longevity signaling pathway AMPK* and contributes to senescent cells, which can play a role in various diseases in old age, to reduce more efficiently.
*AMPK is an enzyme that controls energy metabolism and is involved in regulating processes such as glucose metabolism, mitochondrial function, and inflammatory responses.
Glycine, an amino acid, shows impressive results in animal studies in extending life and influencing various aspects of aging, such as reducing blood sugar levels in diabetics over the long term and improving blood pressure in patients with high blood pressure.
The list continues with theanine, hyaluronic acid, glucosamine, inositol, creatine, magnesium taurate, L-citrulline malate and vitamin C, each of which makes a unique contribution to promoting health and longevity.
The MoleQlar ONE formula combines the best of current research to create a holistic anti-aging experience to offer. With a unique combination of 13 ingredients, it aims to produce various Characteristics of aging to influence — from strengthening the immune system to supporting energy metabolism and reducing inflammation to improving cognitive functions and muscle strength. Thanks to a science-based approach and dosing based on proven research, this product offers a promising opportunity to promote health in old age and enable a longer, more fulfilling life.
It is recommended to take one sachet (1 serving) of MoleQlar ONE daily, with the contents dissolved in 250 ml of liquid and drunk.
Experte
Referenzen
- Zdzisiñska, B., Żurek, A. & Kandefer‐Szerszeń, M. (2016). Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use. Archivum Immunologiae Et Therapiae Experimentalis, 65(1), 21–36. https://doi.org/10.1007/s00005-016-0406-x
- Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer, F. R., Kennedy, B. K. & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8-year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging, 13(22), 24485–24499. https://doi.org/10.18632/aging.203736
- Li, F., Weikel, K., Cacicedo, J. M. & Ido, Y. (2017). Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients, 9(7), 751. https://doi.org/10.3390/nu9070751
- Keylor, M. H., Matsuura, B. S. & Stephenson, C. R. J. (2015). Chemistry and Biology of Resveratrol-Derived Natural Products. Chemical Reviews, 115(17), 8976–9027. https://doi.org/10.1021/cr500689b
- Akter, R., Afrose, A., Rahman, M. R., Chowdhury, R., Nirzhor, S. S. R., Khan, R. I. & Kabir, M. T. (2021). A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes. International Journal Of Molecular Sciences, 22(8), 4180. https://doi.org/10.3390/ijms22084180
- Liu, Y. J., Janssens, G. E., McIntyre, R. L., Molenaars, M., Kamble, R., Gao, A. W., Jongejan, A., Van Weeghel, M., MacInnes, A. W. & Houtkooper, R. H. (2019). Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLOS Genetics, 15(3), e1007633. https://doi.org/10.1371/journal.pgen.1007633
- Kumar, P., Li, C., Suliburk, J. W., Hsu, J. W., Muthupillai, R., Jahoor, F., Minard, C. G., Taffet, G. E. & Sekhar, R. V. (2022). Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. The Journals Of Gerontology: Series A, 78(1), 75–89. https://doi.org/10.1093/gerona/glac135
Publiziert
22.7.2024
Kategorie
Lifestyle
Wissenschaftliche Begriffe
Sirtuin
Enzymes that control longevity: They are found in organisms ranging from yeast to humans and require NAD to function. They remove acetyl and acyl groups from proteins to instruct them to protect cells from adversity, disease, and death. When fasting or exercising, sirtuin and NAD levels rise, which could explain why these activities are healthy. The SIRT genes (Sir2 homologues 1 to 7), which are named after the SIR2 gene in yeast, play a key role in protecting mammals against disease and decay.
NAD
Nicotinamide adenine nucleotide, a chemical used for more than five hundred chemical reactions and for sirtuins, which remove aceryl groups from other proteins, such as histones, to turn off genes or give them cell protective functions. A healthy diet and exercise increase NAD levels. The “+” sign that you sometimes see, as in NAD, indicates that it has no hydrogen aroma.
Cellular Senescence
The process that occurs when normal cells stop dividing and start releasing inflammatory molecules, sometimes caused by telomere shortening, DNA damage, or epigenomic noise. Despite their apparent “zombie” state, senescent cells remain alive and damage neighboring cells with their inflammatory secretions.
Amino Acid
The chemical component of proteins. During the reaction, various amino acids are strung together to form a chain that folds to form a protein.
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