New Drug-Like Molecule Extends Lifespan and Muscle Function
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In a groundbreaking study Researchers have discovered a potential enabler for healthy aging and longevity. The focus is on a natural compound called mitophagy-inducing coumarin (MIC), which is contained in a benzocoumarin compound. This discovery is promising for treating age-related diseases as it targets one of the key players in the aging process — the transcription factor TFEB.
What does that mean?
TFEB is critical for maintaining autophagy lysosome function, a process that is essential for healthy living and preventing age-related diseases. Reduced expression of TFEB has been linked to various age-related disorders, making it a primary target for therapeutic interventions.
The study, which was carried out on the tiny roundworm Caenorhabditis elegans, has shown that MIC significantly extends the lifespan of these organisms. Interestingly, MIC has also shown that it is able to prevent mitochondrial malfunctions in mammalian cells.
Why is that important?
This discovery has far-reaching consequences, as it offers a potential drug-like molecule that improves mitochondrial function and extends life span. For readers of our longevity blog, this opens up new opportunities in their search for better aging and a healthier, longer life. Stay tuned as research in this exciting area will continue to reveal promising paths for the future of longevity and wellbeing.
References
Chamoli, M., Rane, A., Foulger, A., Chinta, S.J., Shahmirzadi, A.A., Kumsta, C., Nambiar, D.K., Hall, D., Holcom, A., Angeli, S., Schmidt, M., Pitteri, S.J., Hansen, M., Lithgow, G. & Andersen, J.K. (2023). A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nature Aging, 3(12), 1529—1543. https://doi.org/10.1038/s43587-023-00524-9
Publiziert
1.7.2024
Kategorie
Science
Experte
In a groundbreaking study Researchers have discovered a potential enabler for healthy aging and longevity. The focus is on a natural compound called mitophagy-inducing coumarin (MIC), which is contained in a benzocoumarin compound. This discovery is promising for treating age-related diseases as it targets one of the key players in the aging process — the transcription factor TFEB.
What does that mean?
TFEB is critical for maintaining autophagy lysosome function, a process that is essential for healthy living and preventing age-related diseases. Reduced expression of TFEB has been linked to various age-related disorders, making it a primary target for therapeutic interventions.
The study, which was carried out on the tiny roundworm Caenorhabditis elegans, has shown that MIC significantly extends the lifespan of these organisms. Interestingly, MIC has also shown that it is able to prevent mitochondrial malfunctions in mammalian cells.
Why is that important?
This discovery has far-reaching consequences, as it offers a potential drug-like molecule that improves mitochondrial function and extends life span. For readers of our longevity blog, this opens up new opportunities in their search for better aging and a healthier, longer life. Stay tuned as research in this exciting area will continue to reveal promising paths for the future of longevity and wellbeing.
Experte
Referenzen
Chamoli, M., Rane, A., Foulger, A., Chinta, S.J., Shahmirzadi, A.A., Kumsta, C., Nambiar, D.K., Hall, D., Holcom, A., Angeli, S., Schmidt, M., Pitteri, S.J., Hansen, M., Lithgow, G. & Andersen, J.K. (2023). A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nature Aging, 3(12), 1529—1543. https://doi.org/10.1038/s43587-023-00524-9
Publiziert
1.7.2024
Kategorie
Science
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