The new dietary supplement NADlife® Energy+ is a synergistic combination of spermidine and NAM, a form of niacin, and is said to improve energy production in the cell. Two important aspects come into play here: mithophagy and mitochondrial respiration.

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Mithophagy is a special form of autophagy, which focuses on mitochondria, the cell's power plants. Spermidine plays a key role in this and promotes the renewal of these important cell organelles. This is particularly interesting for biohackers and athletes, because well-functioning mitochondria are essential for providing energy in the body. In principle, however, every person benefits from renewed mitochondria.

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Mitochondrial respiration, cell respiration, is another crucial process for energy production in cells. This is where niacin comes in the form of nicotinamide (NAM). NAD+ is an important part of this process. However, studies have shown that long-term use of NAM may have drawbacks, including glucose intolerance and insulin spikes.

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Studies on this topic

These negative effects of NAM on glucose metabolism are caused by a study , which shows that glucose intolerance and insulin spikes can lead to significant health problems. However, researchers seem to have found a solution to this problem: concurrent administration of spermidine.

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The study shows that the combination of spermidine and NAM may reduce the disadvantages of taking NAM alone. This was demonstrated on the basis of various measurements such as fasting glucose level, fasting insulin level and glucose tolerance in rats. This is of particular importance as insulin spikes and glucose intolerance are risk factors for the development of type 2 diabetes and other metabolic diseases.

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The findings suggest that spermidine may actually help reduce the adverse side effects of NAM. This could be beneficial not only for people who take NAM for health reasons, but also for those who use NAM as part of anti-aging or energy optimization strategies.

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Cardiovascular system health

It's also worth mentioning that the combination of spermidine and NAM could improve cardiovascular health. Heart failure with preserved ejection fraction (HFpEF) is a common and serious heart condition in which the heart pumps normally but is too stiff to fill up properly.

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One study has shown that patients with HFpEF have lower levels of nicotinamide adenine dinucleotide (NAD+), a key molecule for heart function. Increasing NAD+ levels through nicotinamide supplementation improved diastolic dysfunction in aging mice, rats with high blood pressure, and humans with cardiometabolic syndrome. In addition, nicotinamide directly improved heart muscle flexibility and calcium-dependent relaxation. A cohort study in humans has shown that a diet rich in NAD+ precursors correlates with lower blood pressure and a lower risk of cardiac mortality, suggesting the potential of NAD+ precursors, particularly nicotinamide, in treating diastolic dysfunction and HFpEF in humans.

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Overall, these studies show that NADlife® Energy+ is a promising strategy for promoting cell health and energy production in the body. The combination of spermidine and NAM could be an innovative solution to prevent the potential drawbacks of NAM intake while improving mitochondrial function.

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It will be interesting to see how further research in this area will further clarify the potential benefits and applications of NADlife® Energy+. For people interested in health, anti-aging, and energy optimization, this product could be a promising option in the future.

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About the product

NADlife® Energy+ is characterized by its unique combination of NAM, spermidine and zinc. Zinc contributes to normal DNA and protein synthesis, protects cells from oxidative stress and plays a role in cell division. In addition, zinc is highlighted for its role in maintaining normal acid-base balance, carbohydrate metabolism, macronutrient metabolism, and normal fatty acid metabolism. Niacin, another important ingredient, contributes to normal energy metabolism and helps reduce tiredness and fatigue. Overall, NADlife® Energy+ aims to provide comprehensive support for cell health, metabolism and energy balance.

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About Longevity Labs+

The company based in Graz, Austria Longevity Labs+ strives to play a pioneering role in the trend topic of longevity by developing a scientifically based product portfolio to extend a healthy life span. The company's mission is to put the cell at the center of healthy life, through expertise in cellular health and offering a product portfolio under the motto “Cell Care Program.”

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https://spermidinelife.com